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Biomarker	Exposure to	Matrix	Analytical Technique	Reference
1,3-Butadiene	Tobacco Smoke	ETS	GC-MS
1-Aminonaphthalene (1-AN)	1-Aminonaphthalene	Urine	GC-MS	publication April 2006 Determination of three carcinogenic aromatic amines in urine of smokers and nonsmokers Riedel K, Scherer G, Engl J, Hagedorn H-W, Tricker AR Journal of Analytical Toxicology, Volume 30, doi: 10.1093/jat/30.3.187 publication November 2022 Assessment of the Exposure to Aromatic Amines in Users of Various Tobacco/Nicotine Products Gerhard Scherer, Kirsten Riedel, Nikola Pluym, Max Scherer ACS Omega, doi: 10.1021/acsomega.2c06130
1-Hydroxyphenanthrene (1-OH-Phe)	Phenanthrene	Urine	LC-MS/MS	publication February 2020 Polycyclic aromatic hydrocarbons (PAH) in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V) Murawski A, Roth A, Schwedler G, Schmied-Tobies MIH, Rucic E, Pluym N, Scherer M, Scherer G, Conrad A, Kolossa-Gehring M International Journal of Hygiene and Environmental Health, Volume 226, doi: 10.1016/j.ijheh.2020.113491 publication November 2010 A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for the determination of phenolic polycyclic aromatic hydrocarbons (OH-PAH) in urine of non-smokers and smokers Ramsauer B, Sterz K, Hagedorn H-W, Engl J, Scherer G, McEwan M, Errington G, Shepperd J, Cheung F Analytical and Bioanalytical Chemistry, volume 399, doi:10.1007/s00216-010-4355-7 publication August 2022 Assessment of the exposure to polycyclic aromatic hydrocarbons in users of various tobacco/nicotine products by suitable urinary biomarkers Gerhard Scherer, Max Scherer, Nadine Rögner, Nikola Pluym Archives of Toxicology doi.org/10.1007/s00204-022-03349-4 Conference contribution September 2022 The impact of European legislation on the reduction of Environmental Tobacco Smoke and Polycyclic Aromatic Hydrocarbons between 1995 and 2019 in Germany Therese Burkhardt, Max Scherer, Gerhard Scherer, Till Weber, Nikola Pluym, Marike Kolossa-Gehring ISES 2022, Lisbon publication October 2022 Time trend of exposure to secondhand tobacco smoke and polycyclic aromatic hydrocarbons between 1995 and 2019 in Germany – Showcases for successful European legislation Therese Burkhardt, Max Scherer, Gerhard Scherer, Nikola Pluym, Till Weber, Marike Kolossa-Gehring Environmental Research, doi: 10.1016/j.envres.2022.114638
1-Hydroxypyrene (1-OH-Pyr)	Pyrene	Urine	LC-MS/MS	publication February 2020 Polycyclic aromatic hydrocarbons (PAH) in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V) Murawski A, Roth A, Schwedler G, Schmied-Tobies MIH, Rucic E, Pluym N, Scherer M, Scherer G, Conrad A, Kolossa-Gehring M International Journal of Hygiene and Environmental Health, Volume 226, doi: 10.1016/j.ijheh.2020.113491 publication November 2010 A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for the determination of phenolic polycyclic aromatic hydrocarbons (OH-PAH) in urine of non-smokers and smokers Ramsauer B, Sterz K, Hagedorn H-W, Engl J, Scherer G, McEwan M, Errington G, Shepperd J, Cheung F Analytical and Bioanalytical Chemistry, volume 399, doi:10.1007/s00216-010-4355-7 publication August 2022 Assessment of the exposure to polycyclic aromatic hydrocarbons in users of various tobacco/nicotine products by suitable urinary biomarkers Gerhard Scherer, Max Scherer, Nadine Rögner, Nikola Pluym Archives of Toxicology doi.org/10.1007/s00204-022-03349-4 Conference contribution September 2022 The impact of European legislation on the reduction of Environmental Tobacco Smoke and Polycyclic Aromatic Hydrocarbons between 1995 and 2019 in Germany Therese Burkhardt, Max Scherer, Gerhard Scherer, Till Weber, Nikola Pluym, Marike Kolossa-Gehring ISES 2022, Lisbon publication October 2022 Time trend of exposure to secondhand tobacco smoke and polycyclic aromatic hydrocarbons between 1995 and 2019 in Germany – Showcases for successful European legislation Therese Burkhardt, Max Scherer, Gerhard Scherer, Nikola Pluym, Till Weber, Marike Kolossa-Gehring Environmental Research, doi: 10.1016/j.envres.2022.114638
1-Naphthol (1-Hydroxynaphthalene, 1-OH-Nap)	Naphthalene	Urine	LC-MS/MS	publication February 2020 Polycyclic aromatic hydrocarbons (PAH) in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V) Murawski A, Roth A, Schwedler G, Schmied-Tobies MIH, Rucic E, Pluym N, Scherer M, Scherer G, Conrad A, Kolossa-Gehring M International Journal of Hygiene and Environmental Health, Volume 226, doi: 10.1016/j.ijheh.2020.113491 publication November 2010 A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for the determination of phenolic polycyclic aromatic hydrocarbons (OH-PAH) in urine of non-smokers and smokers Ramsauer B, Sterz K, Hagedorn H-W, Engl J, Scherer G, McEwan M, Errington G, Shepperd J, Cheung F Analytical and Bioanalytical Chemistry, volume 399, doi:10.1007/s00216-010-4355-7 publication August 2022 Assessment of the exposure to polycyclic aromatic hydrocarbons in users of various tobacco/nicotine products by suitable urinary biomarkers Gerhard Scherer, Max Scherer, Nadine Rögner, Nikola Pluym Archives of Toxicology doi.org/10.1007/s00204-022-03349-4 Conference contribution September 2022 The impact of European legislation on the reduction of Environmental Tobacco Smoke and Polycyclic Aromatic Hydrocarbons between 1995 and 2019 in Germany Therese Burkhardt, Max Scherer, Gerhard Scherer, Till Weber, Nikola Pluym, Marike Kolossa-Gehring ISES 2022, Lisbon publication October 2022 Time trend of exposure to secondhand tobacco smoke and polycyclic aromatic hydrocarbons between 1995 and 2019 in Germany – Showcases for successful European legislation Therese Burkhardt, Max Scherer, Gerhard Scherer, Nikola Pluym, Till Weber, Marike Kolossa-Gehring Environmental Research, doi: 10.1016/j.envres.2022.114638
11-dehydro-TXB2	Inflammation	Urine	LC-MS/MS	publication April 2018 Suitability of biomarkers of biological effects (BOBEs) for assessing the likelihood of reducing the tobacco related disease risk by new and innovative tobacco products: A literature review Scherer G Regulatory Toxicology and Pharmacology, Volume 94, doi: 10.1016/j.yrtph.2018.02.002 publication March 2018 Analysis of Urinary Eicosanoids by LC-MS/MS Reveals Alterations in the Metabolic Profile after Smoking Cessation Goettel M, Niessner R, Scherer M, Scherer G, Pluym N Chemical Research in Toxicology, Volume 31, doi: 10.1021/acs.chemrestox publication October 2017 Metabolomic Fingerprinting in Various Body Fluids of a Diet-Controlled Clinical Smoking Cessation Study Using a Validated GC-TOF-MS Metabolomics Platform Goettel M, Niessner R, Mueller D, Scherer M, Scherer G, Pluym N Journal of Proteome Research, Volume 16(10), doi: 10.1021/acs.jproteome.7b00128. publication January 2018 Review of biomarkers to assess the effects of switching from cigarettes to modified risk tobacco products Peck MJ, Sanders EB, Scherer G, Luedicke F, Weitkunat R Biomarkers, Volume 23(3), doi: 10.1080/1354750X.2017.1419284 publication February 2012 A simple and robust UPLC-SRM/MS method to quantify urinary eicosanoids Sterz K, Scherer G, Ecker J Journal of Lipid Research, Volume 53, doi: 10.1194/jlr.D023739 Conference contribution October 2018 Identifying suitable biomarkers of biological effects (BOBEs) for evaluating reduced risk products Scherer G, Pluym N, Scherer M CORESTA Congress 2018, Biomarker Workshop, Kunming, China
12(S)-HETE	Inflammation	Urine	LC-MS/MS	publication April 2018 Suitability of biomarkers of biological effects (BOBEs) for assessing the likelihood of reducing the tobacco related disease risk by new and innovative tobacco products: A literature review Scherer G Regulatory Toxicology and Pharmacology, Volume 94, doi: 10.1016/j.yrtph.2018.02.002 publication March 2018 Analysis of Urinary Eicosanoids by LC-MS/MS Reveals Alterations in the Metabolic Profile after Smoking Cessation Goettel M, Niessner R, Scherer M, Scherer G, Pluym N Chemical Research in Toxicology, Volume 31, doi: 10.1021/acs.chemrestox publication October 2017 Metabolomic Fingerprinting in Various Body Fluids of a Diet-Controlled Clinical Smoking Cessation Study Using a Validated GC-TOF-MS Metabolomics Platform Goettel M, Niessner R, Mueller D, Scherer M, Scherer G, Pluym N Journal of Proteome Research, Volume 16(10), doi: 10.1021/acs.jproteome.7b00128. publication February 2012 A simple and robust UPLC-SRM/MS method to quantify urinary eicosanoids Sterz K, Scherer G, Ecker J Journal of Lipid Research, Volume 53, doi: 10.1194/jlr.D023739
2,3-dinor-8-iso-PGF2α	Oxidative Stress	Urine	LC-MS/MS	publication April 2018 Suitability of biomarkers of biological effects (BOBEs) for assessing the likelihood of reducing the tobacco related disease risk by new and innovative tobacco products: A literature review Scherer G Regulatory Toxicology and Pharmacology, Volume 94, doi: 10.1016/j.yrtph.2018.02.002 publication March 2018 Analysis of Urinary Eicosanoids by LC-MS/MS Reveals Alterations in the Metabolic Profile after Smoking Cessation Goettel M, Niessner R, Scherer M, Scherer G, Pluym N Chemical Research in Toxicology, Volume 31, doi: 10.1021/acs.chemrestox publication October 2017 Metabolomic Fingerprinting in Various Body Fluids of a Diet-Controlled Clinical Smoking Cessation Study Using a Validated GC-TOF-MS Metabolomics Platform Goettel M, Niessner R, Mueller D, Scherer M, Scherer G, Pluym N Journal of Proteome Research, Volume 16(10), doi: 10.1021/acs.jproteome.7b00128. publication February 2012 A simple and robust UPLC-SRM/MS method to quantify urinary eicosanoids Sterz K, Scherer G, Ecker J Journal of Lipid Research, Volume 53, doi: 10.1194/jlr.D023739
2,3-dinor-TXB2	Inflammation	Urine	LC-MS/MS	publication April 2018 Suitability of biomarkers of biological effects (BOBEs) for assessing the likelihood of reducing the tobacco related disease risk by new and innovative tobacco products: A literature review Scherer G Regulatory Toxicology and Pharmacology, Volume 94, doi: 10.1016/j.yrtph.2018.02.002 publication March 2018 Analysis of Urinary Eicosanoids by LC-MS/MS Reveals Alterations in the Metabolic Profile after Smoking Cessation Goettel M, Niessner R, Scherer M, Scherer G, Pluym N Chemical Research in Toxicology, Volume 31, doi: 10.1021/acs.chemrestox publication October 2017 Metabolomic Fingerprinting in Various Body Fluids of a Diet-Controlled Clinical Smoking Cessation Study Using a Validated GC-TOF-MS Metabolomics Platform Goettel M, Niessner R, Mueller D, Scherer M, Scherer G, Pluym N Journal of Proteome Research, Volume 16(10), doi: 10.1021/acs.jproteome.7b00128. publication January 2018 Review of biomarkers to assess the effects of switching from cigarettes to modified risk tobacco products Peck MJ, Sanders EB, Scherer G, Luedicke F, Weitkunat R Biomarkers, Volume 23(3), doi: 10.1080/1354750X.2017.1419284 publication February 2012 A simple and robust UPLC-SRM/MS method to quantify urinary eicosanoids Sterz K, Scherer G, Ecker J Journal of Lipid Research, Volume 53, doi: 10.1194/jlr.D023739 Conference contribution October 2018 Identifying suitable biomarkers of biological effects (BOBEs) for evaluating reduced risk products Scherer G, Pluym N, Scherer M CORESTA Congress 2018, Biomarker Workshop, Kunming, China
2-(Carboxyl-1-methylethyl)mercapturic acid (CMEMA)	Crotonaldehyde	Urine	LC-MS/MS	publication May 2015 Analysis of 18 urinary mercapturic acids by two high-throughput multiplex-LC-MS/MS methods Pluym N, Gilch G, Scherer G, Scherer M Analytical and Bioanalytical Chemistry, Volume 407, doi: 10.1007/s00216-015-8719-x Conference contribution October 2014 Analysis of 18 Urinary Mercapturic Acids by two Multiplex-LC-MS/MS Methods Pluym N, Gilch G, Scherer G, Scherer M CORESTA Congress 2014, Quebec, Canada publication October 2022 Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products Gerhard Scherer, Nikola Pluym, Max Scherer Drug Testing and Analysis DOI: 10.1002/dta.3372
2-Aminonaphthalene (2-AN)	2-Aminonaphthalene	Urine, ETS	GC-MS	publication April 2006 Determination of three carcinogenic aromatic amines in urine of smokers and nonsmokers Riedel K, Scherer G, Engl J, Hagedorn H-W, Tricker AR Journal of Analytical Toxicology, Volume 30, doi: 10.1093/jat/30.3.187 publication November 2022 Assessment of the Exposure to Aromatic Amines in Users of Various Tobacco/Nicotine Products Gerhard Scherer, Kirsten Riedel, Nikola Pluym, Max Scherer ACS Omega, doi: 10.1021/acsomega.2c06130
2-Hydroxy-1-phenylethylmercapturic acid (PHEMA 1)	Styrene	Urine	LC-MS/MS	publication May 2015 Analysis of 18 urinary mercapturic acids by two high-throughput multiplex-LC-MS/MS methods Pluym N, Gilch G, Scherer G, Scherer M Analytical and Bioanalytical Chemistry, Volume 407, doi: 10.1007/s00216-015-8719-x Conference contribution October 2014 Analysis of 18 Urinary Mercapturic Acids by two Multiplex-LC-MS/MS Methods Pluym N, Gilch G, Scherer G, Scherer M CORESTA Congress 2014, Quebec, Canada publication October 2022 Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products Gerhard Scherer, Nikola Pluym, Max Scherer Drug Testing and Analysis DOI: 10.1002/dta.3372
2-Hydroxy-2-phenylethylmercapturic acid (PHEMA 2)	Styrene	Urine	LC-MS/MS	publication May 2015 Analysis of 18 urinary mercapturic acids by two high-throughput multiplex-LC-MS/MS methods Pluym N, Gilch G, Scherer G, Scherer M Analytical and Bioanalytical Chemistry, Volume 407, doi: 10.1007/s00216-015-8719-x Conference contribution October 2014 Analysis of 18 Urinary Mercapturic Acids by two Multiplex-LC-MS/MS Methods Pluym N, Gilch G, Scherer G, Scherer M CORESTA Congress 2014, Quebec, Canada publication October 2022 Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products Gerhard Scherer, Nikola Pluym, Max Scherer Drug Testing and Analysis DOI: 10.1002/dta.3372
2-Hydroxyethylmercapturic acid (HEMA)	Ethylene oxide, Alkylating agents	Urine	LC-MS/MS	publication May 2015 Analysis of 18 urinary mercapturic acids by two high-throughput multiplex-LC-MS/MS methods Pluym N, Gilch G, Scherer G, Scherer M Analytical and Bioanalytical Chemistry, Volume 407, doi: 10.1007/s00216-015-8719-x Conference contribution October 2014 Analysis of 18 Urinary Mercapturic Acids by two Multiplex-LC-MS/MS Methods Pluym N, Gilch G, Scherer G, Scherer M CORESTA Congress 2014, Quebec, Canada Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2018 Analytical methods for the determination of carbonyls in aerosol from e-vapor products and cigarette smoke and their urinary biomarkers of exposure Landmesser A, Scherer M, Scherer G, Pluym N CORESTA Congress 2018, Kunming, China publication October 2022 Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products Gerhard Scherer, Nikola Pluym, Max Scherer Drug Testing and Analysis DOI: 10.1002/dta.3372
2-Hydroxyfluorene (2-OH-Flu)	Fluorene	Urine	LC-MS/MS	publication February 2020 Polycyclic aromatic hydrocarbons (PAH) in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V) Murawski A, Roth A, Schwedler G, Schmied-Tobies MIH, Rucic E, Pluym N, Scherer M, Scherer G, Conrad A, Kolossa-Gehring M International Journal of Hygiene and Environmental Health, Volume 226, doi: 10.1016/j.ijheh.2020.113491 publication November 2010 A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for the determination of phenolic polycyclic aromatic hydrocarbons (OH-PAH) in urine of non-smokers and smokers Ramsauer B, Sterz K, Hagedorn H-W, Engl J, Scherer G, McEwan M, Errington G, Shepperd J, Cheung F Analytical and Bioanalytical Chemistry, volume 399, doi:10.1007/s00216-010-4355-7 publication August 2022 Assessment of the exposure to polycyclic aromatic hydrocarbons in users of various tobacco/nicotine products by suitable urinary biomarkers Gerhard Scherer, Max Scherer, Nadine Rögner, Nikola Pluym Archives of Toxicology doi.org/10.1007/s00204-022-03349-4 Conference contribution September 2022 The impact of European legislation on the reduction of Environmental Tobacco Smoke and Polycyclic Aromatic Hydrocarbons between 1995 and 2019 in Germany Therese Burkhardt, Max Scherer, Gerhard Scherer, Till Weber, Nikola Pluym, Marike Kolossa-Gehring ISES 2022, Lisbon
2-Hydroxyphenanthrene (2-OH-Phe)	Phenanthrene	Urine	LC-MS/MS	publication February 2020 Polycyclic aromatic hydrocarbons (PAH) in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V) Murawski A, Roth A, Schwedler G, Schmied-Tobies MIH, Rucic E, Pluym N, Scherer M, Scherer G, Conrad A, Kolossa-Gehring M International Journal of Hygiene and Environmental Health, Volume 226, doi: 10.1016/j.ijheh.2020.113491 publication November 2010 A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for the determination of phenolic polycyclic aromatic hydrocarbons (OH-PAH) in urine of non-smokers and smokers Ramsauer B, Sterz K, Hagedorn H-W, Engl J, Scherer G, McEwan M, Errington G, Shepperd J, Cheung F Analytical and Bioanalytical Chemistry, volume 399, doi:10.1007/s00216-010-4355-7 publication August 2022 Assessment of the exposure to polycyclic aromatic hydrocarbons in users of various tobacco/nicotine products by suitable urinary biomarkers Gerhard Scherer, Max Scherer, Nadine Rögner, Nikola Pluym Archives of Toxicology doi.org/10.1007/s00204-022-03349-4 Conference contribution September 2022 The impact of European legislation on the reduction of Environmental Tobacco Smoke and Polycyclic Aromatic Hydrocarbons between 1995 and 2019 in Germany Therese Burkhardt, Max Scherer, Gerhard Scherer, Till Weber, Nikola Pluym, Marike Kolossa-Gehring ISES 2022, Lisbon publication October 2022 Time trend of exposure to secondhand tobacco smoke and polycyclic aromatic hydrocarbons between 1995 and 2019 in Germany – Showcases for successful European legislation Therese Burkhardt, Max Scherer, Gerhard Scherer, Nikola Pluym, Till Weber, Marike Kolossa-Gehring Environmental Research, doi: 10.1016/j.envres.2022.114638
2-Hydroxypropylmercapturic acid (2-HPMA)	Propylene oxide	Urine	LC-MS/MS	publication May 2015 Analysis of 18 urinary mercapturic acids by two high-throughput multiplex-LC-MS/MS methods Pluym N, Gilch G, Scherer G, Scherer M Analytical and Bioanalytical Chemistry, Volume 407, doi: 10.1007/s00216-015-8719-x Conference contribution October 2014 Analysis of 18 Urinary Mercapturic Acids by two Multiplex-LC-MS/MS Methods Pluym N, Gilch G, Scherer G, Scherer M CORESTA Congress 2014, Quebec, Canada Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2018 Novel biomarkers to characterize exposure to aldehydes from e-vapor products based on stable-isotope constituents Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA Congress 2018, Kunming, China Conference contribution October 2018 Analytical methods for the determination of carbonyls in aerosol from e-vapor products and cigarette smoke and their urinary biomarkers of exposure Landmesser A, Scherer M, Scherer G, Pluym N CORESTA Congress 2018, Kunming, China Conference contribution October 2019 Analysis of aldehydes, propylene oxide and glycidol in tobacco smoke and e-cigarette vapor and their respective urinary biomarkers Landmesser A, Scherer G, Pluym N, Scherer M CORESTA SSPT 2019, Hamburg, Germany Conference contribution February 2018 Biomarkers of exposure specific to e-vapor products based on stable-isotope labeled ingredients Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N SRNT 2018, Baltimore, USA Conference contribution February 2019 Novel biomarkers to characterize the specific exposure to aldehydes or epoxides from e-vapor products based on stable-isotope labeled constituents Landmesser A, Scherer M, Scherer G, Pluym N SRNT 2019, San Francisco, USA publication June 2021 Assessment of the potential vaping-related exposure to carbonyls and epoxides using stable isotope-labeled precursors in the e-liquid Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Niessner R, Pluym N Archives of Toxicology, doi:10.1007/s00204-021-03097-x publication October 2022 Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products Gerhard Scherer, Nikola Pluym, Max Scherer Drug Testing and Analysis DOI: 10.1002/dta.3372
2-Naphthol (2-Hydroxynaphthalene, 2-OH-Nap)	Naphthalene	Urine	LC-MS/MS	publication February 2020 Polycyclic aromatic hydrocarbons (PAH) in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V) Murawski A, Roth A, Schwedler G, Schmied-Tobies MIH, Rucic E, Pluym N, Scherer M, Scherer G, Conrad A, Kolossa-Gehring M International Journal of Hygiene and Environmental Health, Volume 226, doi: 10.1016/j.ijheh.2020.113491 publication November 2010 A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for the determination of phenolic polycyclic aromatic hydrocarbons (OH-PAH) in urine of non-smokers and smokers Ramsauer B, Sterz K, Hagedorn H-W, Engl J, Scherer G, McEwan M, Errington G, Shepperd J, Cheung F Analytical and Bioanalytical Chemistry, volume 399, doi:10.1007/s00216-010-4355-7 publication August 2022 Assessment of the exposure to polycyclic aromatic hydrocarbons in users of various tobacco/nicotine products by suitable urinary biomarkers Gerhard Scherer, Max Scherer, Nadine Rögner, Nikola Pluym Archives of Toxicology doi.org/10.1007/s00204-022-03349-4 Conference contribution September 2022 The impact of European legislation on the reduction of Environmental Tobacco Smoke and Polycyclic Aromatic Hydrocarbons between 1995 and 2019 in Germany Therese Burkhardt, Max Scherer, Gerhard Scherer, Till Weber, Nikola Pluym, Marike Kolossa-Gehring ISES 2022, Lisbon publication October 2022 Time trend of exposure to secondhand tobacco smoke and polycyclic aromatic hydrocarbons between 1995 and 2019 in Germany – Showcases for successful European legislation Therese Burkhardt, Max Scherer, Gerhard Scherer, Nikola Pluym, Till Weber, Marike Kolossa-Gehring Environmental Research, doi: 10.1016/j.envres.2022.114638
20-Carboxy-Leukotriene B4	Inflammation	Urine	LC-MS/MS	publication April 2018 Suitability of biomarkers of biological effects (BOBEs) for assessing the likelihood of reducing the tobacco related disease risk by new and innovative tobacco products: A literature review Scherer G Regulatory Toxicology and Pharmacology, Volume 94, doi: 10.1016/j.yrtph.2018.02.002 publication October 2017 Metabolomic Fingerprinting in Various Body Fluids of a Diet-Controlled Clinical Smoking Cessation Study Using a Validated GC-TOF-MS Metabolomics Platform Goettel M, Niessner R, Mueller D, Scherer M, Scherer G, Pluym N Journal of Proteome Research, Volume 16(10), doi: 10.1021/acs.jproteome.7b00128.
20-Hydroxy-Leukotriene B4	Inflammation	Urine	LC-MS/MS	publication April 2018 Suitability of biomarkers of biological effects (BOBEs) for assessing the likelihood of reducing the tobacco related disease risk by new and innovative tobacco products: A literature review Scherer G Regulatory Toxicology and Pharmacology, Volume 94, doi: 10.1016/j.yrtph.2018.02.002 publication October 2017 Metabolomic Fingerprinting in Various Body Fluids of a Diet-Controlled Clinical Smoking Cessation Study Using a Validated GC-TOF-MS Metabolomics Platform Goettel M, Niessner R, Mueller D, Scherer M, Scherer G, Pluym N Journal of Proteome Research, Volume 16(10), doi: 10.1021/acs.jproteome.7b00128.
3-Aminobiphenyl (3-ABP)	3-Aminobiphenyl	Urine	GC-MS	publication April 2006 Determination of three carcinogenic aromatic amines in urine of smokers and nonsmokers Riedel K, Scherer G, Engl J, Hagedorn H-W, Tricker AR Journal of Analytical Toxicology, Volume 30, doi: 10.1093/jat/30.3.187 publication November 2022 Assessment of the Exposure to Aromatic Amines in Users of Various Tobacco/Nicotine Products Gerhard Scherer, Kirsten Riedel, Nikola Pluym, Max Scherer ACS Omega, doi: 10.1021/acsomega.2c06130
3-Ethenylpyridine	Tobacco Smoke	Environmental Tobacco Smoke (ETS)	GC-MS
3-Hydroxy-1-methylpropylmercapturic acid (HMPMA)	Crotonaldehyde	Urine	LC-MS/MS	publication May 2015 Analysis of 18 urinary mercapturic acids by two high-throughput multiplex-LC-MS/MS methods Pluym N, Gilch G, Scherer G, Scherer M Analytical and Bioanalytical Chemistry, Volume 407, doi: 10.1007/s00216-015-8719-x Conference contribution October 2014 Analysis of 18 Urinary Mercapturic Acids by two Multiplex-LC-MS/MS Methods Pluym N, Gilch G, Scherer G, Scherer M CORESTA Congress 2014, Quebec, Canada Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria publication June 2021 Assessment of the potential vaping-related exposure to carbonyls and epoxides using stable isotope-labeled precursors in the e-liquid Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Niessner R, Pluym N Archives of Toxicology, doi:10.1007/s00204-021-03097-x publication October 2022 Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products Gerhard Scherer, Nikola Pluym, Max Scherer Drug Testing and Analysis DOI: 10.1002/dta.3372
3-Hydroxyphenanthrene (3-OH-Phe)	Phenanthrene	Urine	LC-MS/MS	publication February 2020 Polycyclic aromatic hydrocarbons (PAH) in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V) Murawski A, Roth A, Schwedler G, Schmied-Tobies MIH, Rucic E, Pluym N, Scherer M, Scherer G, Conrad A, Kolossa-Gehring M International Journal of Hygiene and Environmental Health, Volume 226, doi: 10.1016/j.ijheh.2020.113491 publication November 2010 A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for the determination of phenolic polycyclic aromatic hydrocarbons (OH-PAH) in urine of non-smokers and smokers Ramsauer B, Sterz K, Hagedorn H-W, Engl J, Scherer G, McEwan M, Errington G, Shepperd J, Cheung F Analytical and Bioanalytical Chemistry, volume 399, doi:10.1007/s00216-010-4355-7 publication August 2022 Assessment of the exposure to polycyclic aromatic hydrocarbons in users of various tobacco/nicotine products by suitable urinary biomarkers Gerhard Scherer, Max Scherer, Nadine Rögner, Nikola Pluym Archives of Toxicology doi.org/10.1007/s00204-022-03349-4 Conference contribution September 2022 The impact of European legislation on the reduction of Environmental Tobacco Smoke and Polycyclic Aromatic Hydrocarbons between 1995 and 2019 in Germany Therese Burkhardt, Max Scherer, Gerhard Scherer, Till Weber, Nikola Pluym, Marike Kolossa-Gehring ISES 2022, Lisbon publication October 2022 Time trend of exposure to secondhand tobacco smoke and polycyclic aromatic hydrocarbons between 1995 and 2019 in Germany – Showcases for successful European legislation Therese Burkhardt, Max Scherer, Gerhard Scherer, Nikola Pluym, Till Weber, Marike Kolossa-Gehring Environmental Research, doi: 10.1016/j.envres.2022.114638
3-Hydroxypropylmercapturic acid (3-HPMA)	Acrolein	Urine	LC-MS/MS	publication May 2015 Analysis of 18 urinary mercapturic acids by two high-throughput multiplex-LC-MS/MS methods Pluym N, Gilch G, Scherer G, Scherer M Analytical and Bioanalytical Chemistry, Volume 407, doi: 10.1007/s00216-015-8719-x Conference contribution October 2014 Analysis of 18 Urinary Mercapturic Acids by two Multiplex-LC-MS/MS Methods Pluym N, Gilch G, Scherer G, Scherer M CORESTA Congress 2014, Quebec, Canada Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2018 Novel biomarkers to characterize exposure to aldehydes from e-vapor products based on stable-isotope constituents Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA Congress 2018, Kunming, China Conference contribution October 2018 Analytical methods for the determination of carbonyls in aerosol from e-vapor products and cigarette smoke and their urinary biomarkers of exposure Landmesser A, Scherer M, Scherer G, Pluym N CORESTA Congress 2018, Kunming, China Conference contribution October 2019 Analysis of aldehydes, propylene oxide and glycidol in tobacco smoke and e-cigarette vapor and their respective urinary biomarkers Landmesser A, Scherer G, Pluym N, Scherer M CORESTA SSPT 2019, Hamburg, Germany Conference contribution February 2018 Biomarkers of exposure specific to e-vapor products based on stable-isotope labeled ingredients Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N SRNT 2018, Baltimore, USA Conference contribution February 2019 Novel biomarkers to characterize the specific exposure to aldehydes or epoxides from e-vapor products based on stable-isotope labeled constituents Landmesser A, Scherer M, Scherer G, Pluym N SRNT 2019, San Francisco, USA publication June 2021 Assessment of the potential vaping-related exposure to carbonyls and epoxides using stable isotope-labeled precursors in the e-liquid Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Niessner R, Pluym N Archives of Toxicology, doi:10.1007/s00204-021-03097-x publication October 2022 Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products Gerhard Scherer, Nikola Pluym, Max Scherer Drug Testing and Analysis DOI: 10.1002/dta.3372
3-Nitrotyrosine	Nitrosative stress	Plasma	LC-MS/MS
3-hydroxybenzo[a]pyrene (3-OH-BaP)	Benzo[a]pyrene	Urine	LC-MS/MS	Conference contribution June 2021 Analysis of 3-hydroxybenzo[a]pyrene in urine as a biomarker of exposure for benzo[a]pyrene in smokers and users of potentially reduced risk products Rögner N, Scherer M, Scherer G, Pluym N Global Forum on Nicotine 2021, Virtual publication October 2021 A Sensitive LC–MS/MS Method for the Quantification of 3-Hydroxybenzo[a]pyrene in Urine-Exposure Assessment in Smokers and Users of Potentially Reduced-Risk Products Rögner N, Hagedorn H-W, Scherer G, Scherer M, Pluym N Separations, 8(10), 171, doi: 10.3390/separations8100171 Conference contribution October 2021 Analysis of 3-hydroxybenzo[a]pyrene in urine as a biomarker of exposure for benzo[a]pyrene in smokers and users of potentially reduced risk products Scherer M, Rögner N, Scherer G, Pluym N CORESTA SSPT 2021, Virtual publication October 2022 Time trend of exposure to secondhand tobacco smoke and polycyclic aromatic hydrocarbons between 1995 and 2019 in Germany – Showcases for successful European legislation Therese Burkhardt, Max Scherer, Gerhard Scherer, Nikola Pluym, Till Weber, Marike Kolossa-Gehring Environmental Research, doi: 10.1016/j.envres.2022.114638
4-Aminobiphenyl (4-ABP)	4-Aminobiphenyl	Urine, ETS	GC-MS	publication April 2014 A correlation study applied to biomarkers of internal and effective dose for acrylonitrile and 4-aminobiphenyl in smokers Scherer G, Newland K, Papadopoulou E, Minet E Biomarkers, Volume 19(4), doi: 10.3109/1354750X.2014.910271 publication April 2006 Determination of three carcinogenic aromatic amines in urine of smokers and nonsmokers Riedel K, Scherer G, Engl J, Hagedorn H-W, Tricker AR Journal of Analytical Toxicology, Volume 30, doi: 10.1093/jat/30.3.187 publication November 2022 Assessment of the Exposure to Aromatic Amines in Users of Various Tobacco/Nicotine Products Gerhard Scherer, Kirsten Riedel, Nikola Pluym, Max Scherer ACS Omega, doi: 10.1021/acsomega.2c06130
4-Hydroxy-4-(3-pyridyl)butanoic acid (HyPyBut)	Nicotine	Urine	LC-MS/MS	publication March 2019 Biomarkers of Exposure Specific to E-vapor Products Based on Stable-Isotope Labeled Ingredients Landmesser A, Scherer M, Pluym N, Sarkar M, Edmiston J, Niessner R, Scherer G Nicotine & Tobacco Research, Volume 21, doi: 10.1093/ntr/nty204 publication May 2018 Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine Wang L, Bernert JT, Benowitz NL, Feng J, Jacob P 3rd, McGahee E, Caudill SP, Scherer G, Scherer M, Pluym N, Doig MV, Newland K, Murphy SE, Caron NJ, Sander LC, Shimizu M, Yamazaki H, Kim S, Langman LJ, Pritchett JS, Sniegoski LT, Li Y, Blount BC, Pirkle JL Cancer Epidemiology, Biomarkers & Prevention, Volume 27, doi: 10.1158/1055-9965 publication January 2014 Simple, fast and sensitive LC-MS/MS analysis for the simultaneous quantification of nicotine and 10 of its major metabolites Piller M, Gilch G, Scherer G, Scherer M Journal of Chromatography B, Volumes 951–952, doi: 10.1016/j.jchromb.2014.01.025 Conference contribution October 2013 Assessing the exposure to ‘smoke’ from electronic cigarettes by biomarkers Scherer G, Hagedorn H-W, Riedel K, Scherer M CORESTA SSPT 2013, Seville, Spain Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–study design Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution February 2018 Biomarkers of exposure specific to e-vapor products based on stable-isotope labeled ingredients Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N SRNT 2018, Baltimore, USA publication March 2022 Assessment of nicotine delivery and uptake in users of various tobacco / nicotine products Scherer G, Mütze J, Pluym N, Scherer M Current Research in Toxicology, Volume 3, 100067
4-Hydroxyphenanthrene (4-OH-Phe)	Phenanthrene	Urine	LC-MS/MS	publication February 2020 Polycyclic aromatic hydrocarbons (PAH) in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V) Murawski A, Roth A, Schwedler G, Schmied-Tobies MIH, Rucic E, Pluym N, Scherer M, Scherer G, Conrad A, Kolossa-Gehring M International Journal of Hygiene and Environmental Health, Volume 226, doi: 10.1016/j.ijheh.2020.113491 publication November 2010 A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for the determination of phenolic polycyclic aromatic hydrocarbons (OH-PAH) in urine of non-smokers and smokers Ramsauer B, Sterz K, Hagedorn H-W, Engl J, Scherer G, McEwan M, Errington G, Shepperd J, Cheung F Analytical and Bioanalytical Chemistry, volume 399, doi:10.1007/s00216-010-4355-7 publication August 2022 Assessment of the exposure to polycyclic aromatic hydrocarbons in users of various tobacco/nicotine products by suitable urinary biomarkers Gerhard Scherer, Max Scherer, Nadine Rögner, Nikola Pluym Archives of Toxicology doi.org/10.1007/s00204-022-03349-4 Conference contribution September 2022 The impact of European legislation on the reduction of Environmental Tobacco Smoke and Polycyclic Aromatic Hydrocarbons between 1995 and 2019 in Germany Therese Burkhardt, Max Scherer, Gerhard Scherer, Till Weber, Nikola Pluym, Marike Kolossa-Gehring ISES 2022, Lisbon publication October 2022 Time trend of exposure to secondhand tobacco smoke and polycyclic aromatic hydrocarbons between 1995 and 2019 in Germany – Showcases for successful European legislation Therese Burkhardt, Max Scherer, Gerhard Scherer, Nikola Pluym, Till Weber, Marike Kolossa-Gehring Environmental Research, doi: 10.1016/j.envres.2022.114638
8-Hydroxy-deoxyguanosine (8-OH-dG)	Oxidative stress	Urine	LC-MS/MS	publication April 2018 Suitability of biomarkers of biological effects (BOBEs) for assessing the likelihood of reducing the tobacco related disease risk by new and innovative tobacco products: A literature review Scherer G Regulatory Toxicology and Pharmacology, Volume 94, doi: 10.1016/j.yrtph.2018.02.002 publication October 2017 Metabolomic Fingerprinting in Various Body Fluids of a Diet-Controlled Clinical Smoking Cessation Study Using a Validated GC-TOF-MS Metabolomics Platform Goettel M, Niessner R, Mueller D, Scherer M, Scherer G, Pluym N Journal of Proteome Research, Volume 16(10), doi: 10.1021/acs.jproteome.7b00128. Conference contribution October 2018 Identifying suitable biomarkers of biological effects (BOBEs) for evaluating reduced risk products Scherer G, Pluym N, Scherer M CORESTA Congress 2018, Biomarker Workshop, Kunming, China
8-iso-PGF2α	Oxidative Stress	Urine	LC-MS/MS	publication April 2018 Suitability of biomarkers of biological effects (BOBEs) for assessing the likelihood of reducing the tobacco related disease risk by new and innovative tobacco products: A literature review Scherer G Regulatory Toxicology and Pharmacology, Volume 94, doi: 10.1016/j.yrtph.2018.02.002 publication March 2018 Analysis of Urinary Eicosanoids by LC-MS/MS Reveals Alterations in the Metabolic Profile after Smoking Cessation Goettel M, Niessner R, Scherer M, Scherer G, Pluym N Chemical Research in Toxicology, Volume 31, doi: 10.1021/acs.chemrestox publication October 2017 Metabolomic Fingerprinting in Various Body Fluids of a Diet-Controlled Clinical Smoking Cessation Study Using a Validated GC-TOF-MS Metabolomics Platform Goettel M, Niessner R, Mueller D, Scherer M, Scherer G, Pluym N Journal of Proteome Research, Volume 16(10), doi: 10.1021/acs.jproteome.7b00128. publication January 2018 Review of biomarkers to assess the effects of switching from cigarettes to modified risk tobacco products Peck MJ, Sanders EB, Scherer G, Luedicke F, Weitkunat R Biomarkers, Volume 23(3), doi: 10.1080/1354750X.2017.1419284 publication February 2012 A simple and robust UPLC-SRM/MS method to quantify urinary eicosanoids Sterz K, Scherer G, Ecker J Journal of Lipid Research, Volume 53, doi: 10.1194/jlr.D023739 Conference contribution October 2018 Identifying suitable biomarkers of biological effects (BOBEs) for evaluating reduced risk products Scherer G, Pluym N, Scherer M CORESTA Congress 2018, Biomarker Workshop, Kunming, China
9-Hydroxyphenanthrene (9-OH-Phe)	Phenanthrene	Urine	LC-MS/MS	publication February 2020 Polycyclic aromatic hydrocarbons (PAH) in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V) Murawski A, Roth A, Schwedler G, Schmied-Tobies MIH, Rucic E, Pluym N, Scherer M, Scherer G, Conrad A, Kolossa-Gehring M International Journal of Hygiene and Environmental Health, Volume 226, doi: 10.1016/j.ijheh.2020.113491 publication November 2010 A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for the determination of phenolic polycyclic aromatic hydrocarbons (OH-PAH) in urine of non-smokers and smokers Ramsauer B, Sterz K, Hagedorn H-W, Engl J, Scherer G, McEwan M, Errington G, Shepperd J, Cheung F Analytical and Bioanalytical Chemistry, volume 399, doi:10.1007/s00216-010-4355-7 publication August 2022 Assessment of the exposure to polycyclic aromatic hydrocarbons in users of various tobacco/nicotine products by suitable urinary biomarkers Gerhard Scherer, Max Scherer, Nadine Rögner, Nikola Pluym Archives of Toxicology doi.org/10.1007/s00204-022-03349-4 Conference contribution September 2022 The impact of European legislation on the reduction of Environmental Tobacco Smoke and Polycyclic Aromatic Hydrocarbons between 1995 and 2019 in Germany Therese Burkhardt, Max Scherer, Gerhard Scherer, Till Weber, Nikola Pluym, Marike Kolossa-Gehring ISES 2022, Lisbon publication October 2022 Time trend of exposure to secondhand tobacco smoke and polycyclic aromatic hydrocarbons between 1995 and 2019 in Germany – Showcases for successful European legislation Therese Burkhardt, Max Scherer, Gerhard Scherer, Nikola Pluym, Till Weber, Marike Kolossa-Gehring Environmental Research, doi: 10.1016/j.envres.2022.114638
Acetaldehyde (FA)	Tobacco Smoke, E-Vapor Aerosol	ETS, e-liquids, aerosol	LC-MS/MS
Acetone	Tobacco Smoke, E-Vapor Aerosol	ETS, e-liquids, aerosol	LC-MS/MS
Acrolein (ACR)	Tobacco Smoke, E-Vapor Aerosol	ETS, e-liquids, aerosol	LC-MS/MS
Acrylamidemercapturic acid (AAMA)	Acrylamide	Urine	LC-MS/MS	publication October 2020 Benzene metabolite SPMA and acrylamide metabolites AAMA and GAMA in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V) Schwedler G, Murawski A, Schmied-Tobies MIH, Rucic E, Scherer M, Pluym N, Scherer G, Bethke R, Kolossa-Gehring M Environmental Research, Volume 192, doi: 10.1016/j.envres.2020.110295 publication May 2015 Analysis of 18 urinary mercapturic acids by two high-throughput multiplex-LC-MS/MS methods Pluym N, Gilch G, Scherer G, Scherer M Analytical and Bioanalytical Chemistry, Volume 407, doi: 10.1007/s00216-015-8719-x publication March 2006 Urinary Mercapturic Acids and a Hemoglobin Adduct for the Dosimetry of Acrylamide Exposure in Smokers and Nonsmokers Urban M, Kavvadias D, Riedel K, Scherer G, Tricker AR Inhalation Toxicology, Volume 18, doi: 10.1080/08958370600748430 Conference contribution October 2014 Analysis of 18 Urinary Mercapturic Acids by two Multiplex-LC-MS/MS Methods Pluym N, Gilch G, Scherer G, Scherer M CORESTA Congress 2014, Quebec, Canada publication October 2022 Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products Gerhard Scherer, Nikola Pluym, Max Scherer Drug Testing and Analysis DOI: 10.1002/dta.3372
Anabasine (AB)	Anabasine	Plasma, Urine	LC-MS/MS
Anatabine (AT)	Anatabine	Plasma, Urine	LC-MS/MS
Benzene	Tobacco Smoke	ETS	GC-MS
Benzo[a]pyrene (BaP)	PAH	ETS	GC-MS
Benzo[a]pyrene tetrol (BaP-tetrol)	Benzo[a]pyrene	Urine	GC-MS/MS
Citronellol	Flavor	Urine	HS-SPME-GC-MS
Cotinine	Nicotine	Urine, Plasma, Serum, Saliva	LC-MS/MS	publication March 2019 Biomarkers of Exposure Specific to E-vapor Products Based on Stable-Isotope Labeled Ingredients Landmesser A, Scherer M, Pluym N, Sarkar M, Edmiston J, Niessner R, Scherer G Nicotine & Tobacco Research, Volume 21, doi: 10.1093/ntr/nty204 publication May 2018 Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine Wang L, Bernert JT, Benowitz NL, Feng J, Jacob P 3rd, McGahee E, Caudill SP, Scherer G, Scherer M, Pluym N, Doig MV, Newland K, Murphy SE, Caron NJ, Sander LC, Shimizu M, Yamazaki H, Kim S, Langman LJ, Pritchett JS, Sniegoski LT, Li Y, Blount BC, Pirkle JL Cancer Epidemiology, Biomarkers & Prevention, Volume 27, doi: 10.1158/1055-9965 publication March 2014 Saliva as a matrix for human biomonitoring in occupational and environmental medicine Michalke B, Rossbach B, Göen T, Schäferhenrich A, Scherer G International Archives of Occupational and Environmental Health, volume 88, doi: 10.1007/s00420-014-0938-5 publication January 2014 Simple, fast and sensitive LC-MS/MS analysis for the simultaneous quantification of nicotine and 10 of its major metabolites Piller M, Gilch G, Scherer G, Scherer M Journal of Chromatography B, Volumes 951–952, doi: 10.1016/j.jchromb.2014.01.025 publication February 2014 Untargeted metabolomic profiling in saliva of smokers and nonsmokers by a validated GC-TOF-MS method Mueller DC, Piller M, Niessner R, Scherer M, Scherer G Journal of Proteome Research, Volume 13, doi: 10.1021/pr401099r Conference contribution October 2013 Assessing the exposure to ‘smoke’ from electronic cigarettes by biomarkers Scherer G, Hagedorn H-W, Riedel K, Scherer M CORESTA SSPT 2013, Seville, Spain Conference contribution October 2016 Ultra-sensitive method for the determination of nicotine in PK studies with next generation products Wanderer F, Pluym N, Scherer G, Scherer M CORESTA Congress 2016, Berlin, Germany Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–study design Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution February 2018 Biomarkers of exposure specific to e-vapor products based on stable-isotope labeled ingredients Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N SRNT 2018, Baltimore, USA publication March 2022 Assessment of nicotine delivery and uptake in users of various tobacco / nicotine products Scherer G, Mütze J, Pluym N, Scherer M Current Research in Toxicology, Volume 3, 100067 publication September 2022 Urinary cotinine and exposure to passive smoke in children and adolescents in Germany – Human biomonitoring results of the German Environmental Survey 2014–2017 (GerES V) Domenica Hahn, Maria Schmied-Tobies, Enrico Rucic, Nikola Pluym, Max Scherer, Malgorzata Debiak, Aline Murawski, Marike Kolossa-Gehring Environmental Research doi.org/10.1016/j.envres.2022.114320 Conference contribution September 2022 The impact of European legislation on the reduction of Environmental Tobacco Smoke and Polycyclic Aromatic Hydrocarbons between 1995 and 2019 in Germany Therese Burkhardt, Max Scherer, Gerhard Scherer, Till Weber, Nikola Pluym, Marike Kolossa-Gehring ISES 2022, Lisbon publication October 2022 Time trend of exposure to secondhand tobacco smoke and polycyclic aromatic hydrocarbons between 1995 and 2019 in Germany – Showcases for successful European legislation Therese Burkhardt, Max Scherer, Gerhard Scherer, Nikola Pluym, Till Weber, Marike Kolossa-Gehring Environmental Research, doi: 10.1016/j.envres.2022.114638
Cotinine-N-oxide (CNO)	Nicotine	Urine	LC-MS/MS	publication March 2019 Biomarkers of Exposure Specific to E-vapor Products Based on Stable-Isotope Labeled Ingredients Landmesser A, Scherer M, Pluym N, Sarkar M, Edmiston J, Niessner R, Scherer G Nicotine & Tobacco Research, Volume 21, doi: 10.1093/ntr/nty204 publication May 2018 Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine Wang L, Bernert JT, Benowitz NL, Feng J, Jacob P 3rd, McGahee E, Caudill SP, Scherer G, Scherer M, Pluym N, Doig MV, Newland K, Murphy SE, Caron NJ, Sander LC, Shimizu M, Yamazaki H, Kim S, Langman LJ, Pritchett JS, Sniegoski LT, Li Y, Blount BC, Pirkle JL Cancer Epidemiology, Biomarkers & Prevention, Volume 27, doi: 10.1158/1055-9965 publication January 2014 Simple, fast and sensitive LC-MS/MS analysis for the simultaneous quantification of nicotine and 10 of its major metabolites Piller M, Gilch G, Scherer G, Scherer M Journal of Chromatography B, Volumes 951–952, doi: 10.1016/j.jchromb.2014.01.025 Conference contribution October 2013 Assessing the exposure to ‘smoke’ from electronic cigarettes by biomarkers Scherer G, Hagedorn H-W, Riedel K, Scherer M CORESTA SSPT 2013, Seville, Spain Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–study design Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution February 2018 Biomarkers of exposure specific to e-vapor products based on stable-isotope labeled ingredients Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N SRNT 2018, Baltimore, USA publication March 2022 Assessment of nicotine delivery and uptake in users of various tobacco / nicotine products Scherer G, Mütze J, Pluym N, Scherer M Current Research in Toxicology, Volume 3, 100067
Cotinine-glucuronide	Nicotine	Urine	LC-MS/MS	publication March 2019 Biomarkers of Exposure Specific to E-vapor Products Based on Stable-Isotope Labeled Ingredients Landmesser A, Scherer M, Pluym N, Sarkar M, Edmiston J, Niessner R, Scherer G Nicotine & Tobacco Research, Volume 21, doi: 10.1093/ntr/nty204 publication May 2018 Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine Wang L, Bernert JT, Benowitz NL, Feng J, Jacob P 3rd, McGahee E, Caudill SP, Scherer G, Scherer M, Pluym N, Doig MV, Newland K, Murphy SE, Caron NJ, Sander LC, Shimizu M, Yamazaki H, Kim S, Langman LJ, Pritchett JS, Sniegoski LT, Li Y, Blount BC, Pirkle JL Cancer Epidemiology, Biomarkers & Prevention, Volume 27, doi: 10.1158/1055-9965 publication January 2014 Simple, fast and sensitive LC-MS/MS analysis for the simultaneous quantification of nicotine and 10 of its major metabolites Piller M, Gilch G, Scherer G, Scherer M Journal of Chromatography B, Volumes 951–952, doi: 10.1016/j.jchromb.2014.01.025 Conference contribution October 2013 Assessing the exposure to ‘smoke’ from electronic cigarettes by biomarkers Scherer G, Hagedorn H-W, Riedel K, Scherer M CORESTA SSPT 2013, Seville, Spain Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–study design Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution February 2018 Biomarkers of exposure specific to e-vapor products based on stable-isotope labeled ingredients Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N SRNT 2018, Baltimore, USA publication March 2022 Assessment of nicotine delivery and uptake in users of various tobacco / nicotine products Scherer G, Mütze J, Pluym N, Scherer M Current Research in Toxicology, Volume 3, 100067
Creatinine	Normalization of urinary biomarker concentrations	Urine	Photometry
Cyanoethylmercapturic acid (CEMA)	Acrylonitrile	Urine	LC-MS/MS	publication May 2015 Analysis of 18 urinary mercapturic acids by two high-throughput multiplex-LC-MS/MS methods Pluym N, Gilch G, Scherer G, Scherer M Analytical and Bioanalytical Chemistry, Volume 407, doi: 10.1007/s00216-015-8719-x publication April 2014 A correlation study applied to biomarkers of internal and effective dose for acrylonitrile and 4-aminobiphenyl in smokers Scherer G, Newland K, Papadopoulou E, Minet E Biomarkers, Volume 19(4), doi: 10.3109/1354750X.2014.910271 Conference contribution October 2014 Analysis of 18 Urinary Mercapturic Acids by two Multiplex-LC-MS/MS Methods Pluym N, Gilch G, Scherer G, Scherer M CORESTA Congress 2014, Quebec, Canada publication October 2022 Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products Gerhard Scherer, Nikola Pluym, Max Scherer Drug Testing and Analysis DOI: 10.1002/dta.3372
DHN-MA	Oxidative stress, Lipid peroxidation	Urine	LC-MS/MS
Dihydroxybutenylmercapturic acid (DHBMA)	1,3-Butadiene	Urine	LC-MS/MS	publication May 2015 Analysis of 18 urinary mercapturic acids by two high-throughput multiplex-LC-MS/MS methods Pluym N, Gilch G, Scherer G, Scherer M Analytical and Bioanalytical Chemistry, Volume 407, doi: 10.1007/s00216-015-8719-x Conference contribution October 2014 Analysis of 18 Urinary Mercapturic Acids by two Multiplex-LC-MS/MS Methods Pluym N, Gilch G, Scherer G, Scherer M CORESTA Congress 2014, Quebec, Canada publication October 2022 Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products Gerhard Scherer, Nikola Pluym, Max Scherer Drug Testing and Analysis DOI: 10.1002/dta.3372
Dihydroxypropylmercapturic acid (DHPMA)	Glycidol	Urine	LC-MS/MS	Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2018 Novel biomarkers to characterize exposure to aldehydes from e-vapor products based on stable-isotope constituents Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA Congress 2018, Kunming, China Conference contribution October 2018 Analytical methods for the determination of carbonyls in aerosol from e-vapor products and cigarette smoke and their urinary biomarkers of exposure Landmesser A, Scherer M, Scherer G, Pluym N CORESTA Congress 2018, Kunming, China Conference contribution October 2019 Analysis of aldehydes, propylene oxide and glycidol in tobacco smoke and e-cigarette vapor and their respective urinary biomarkers Landmesser A, Scherer G, Pluym N, Scherer M CORESTA SSPT 2019, Hamburg, Germany Conference contribution February 2018 Biomarkers of exposure specific to e-vapor products based on stable-isotope labeled ingredients Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N SRNT 2018, Baltimore, USA Conference contribution February 2019 Novel biomarkers to characterize the specific exposure to aldehydes or epoxides from e-vapor products based on stable-isotope labeled constituents Landmesser A, Scherer M, Scherer G, Pluym N SRNT 2019, San Francisco, USA publication June 2021 Assessment of the potential vaping-related exposure to carbonyls and epoxides using stable isotope-labeled precursors in the e-liquid Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Niessner R, Pluym N Archives of Toxicology, doi:10.1007/s00204-021-03097-x publication October 2022 Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products Gerhard Scherer, Nikola Pluym, Max Scherer Drug Testing and Analysis DOI: 10.1002/dta.3372
Eugenol	Flavor	Urine	HS-SPME-GC-MS
F-PM	Tobacco Smoke	Environmental Tobacco Smoke (ETS)	Fluorescence
Fromaldehyde (FA)	Tobacco Smoke, E-Vapor, Aerosol	ETS, e-liquids, aerosol	LC-MS/MS
Glycerol	Glycerol	Urine, Plasma, Serum, Saliva, PBS, ETS, Aerosol, e-liquids	LC-MS/MS	publication March 2019 Biomarkers of Exposure Specific to E-vapor Products Based on Stable-Isotope Labeled Ingredients Landmesser A, Scherer M, Pluym N, Sarkar M, Edmiston J, Niessner R, Scherer G Nicotine & Tobacco Research, Volume 21, doi: 10.1093/ntr/nty204 Conference contribution October 2013 Assessing the exposure to ‘smoke’ from electronic cigarettes by biomarkers Scherer G, Hagedorn H-W, Riedel K, Scherer M CORESTA SSPT 2013, Seville, Spain Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–study design Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution February 2018 Biomarkers of exposure specific to e-vapor products based on stable-isotope labeled ingredients Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N SRNT 2018, Baltimore, USA
Glycidamidemercapturic acid (GAMA)	Acrylamide	Urine	LC-MS/MS	publication October 2020 Benzene metabolite SPMA and acrylamide metabolites AAMA and GAMA in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V) Schwedler G, Murawski A, Schmied-Tobies MIH, Rucic E, Scherer M, Pluym N, Scherer G, Bethke R, Kolossa-Gehring M Environmental Research, Volume 192, doi: 10.1016/j.envres.2020.110295 publication May 2015 Analysis of 18 urinary mercapturic acids by two high-throughput multiplex-LC-MS/MS methods Pluym N, Gilch G, Scherer G, Scherer M Analytical and Bioanalytical Chemistry, Volume 407, doi: 10.1007/s00216-015-8719-x publication March 2006 Urinary Mercapturic Acids and a Hemoglobin Adduct for the Dosimetry of Acrylamide Exposure in Smokers and Nonsmokers Urban M, Kavvadias D, Riedel K, Scherer G, Tricker AR Inhalation Toxicology, Volume 18, doi: 10.1080/08958370600748430 Conference contribution October 2014 Analysis of 18 Urinary Mercapturic Acids by two Multiplex-LC-MS/MS Methods Pluym N, Gilch G, Scherer G, Scherer M CORESTA Congress 2014, Quebec, Canada publication October 2022 Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products Gerhard Scherer, Nikola Pluym, Max Scherer Drug Testing and Analysis DOI: 10.1002/dta.3372
HNA-Lactone-MA	Oxidative stress, Lipid peroxidation	Urine	LC-MS/MS
HNA-MA	Oxidative stress, Lipid peroxidation	Urine	LC-MS/MS
HNE-MA	Oxidative stress, Lipid peroxidation	Urine	LC-MS/MS
Homocysteine	Amino acid metabolism	Plasma	LC-MS/MS
Isoprenemercapturic acid (IPMA-3)	Isoprene	Urine	LC-MS/MS
L-Carvone	Flavor	Urine	HS-SPME-GC-MS
Leukotriene E4	Inflammation	Urine	LC-MS/MS	publication April 2018 Suitability of biomarkers of biological effects (BOBEs) for assessing the likelihood of reducing the tobacco related disease risk by new and innovative tobacco products: A literature review Scherer G Regulatory Toxicology and Pharmacology, Volume 94, doi: 10.1016/j.yrtph.2018.02.002 publication March 2018 Analysis of Urinary Eicosanoids by LC-MS/MS Reveals Alterations in the Metabolic Profile after Smoking Cessation Goettel M, Niessner R, Scherer M, Scherer G, Pluym N Chemical Research in Toxicology, Volume 31, doi: 10.1021/acs.chemrestox publication October 2017 Metabolomic Fingerprinting in Various Body Fluids of a Diet-Controlled Clinical Smoking Cessation Study Using a Validated GC-TOF-MS Metabolomics Platform Goettel M, Niessner R, Mueller D, Scherer M, Scherer G, Pluym N Journal of Proteome Research, Volume 16(10), doi: 10.1021/acs.jproteome.7b00128. publication February 2012 A simple and robust UPLC-SRM/MS method to quantify urinary eicosanoids Sterz K, Scherer G, Ecker J Journal of Lipid Research, Volume 53, doi: 10.1194/jlr.D023739
Linalool	Flavor	Urine	HS-SPME-GC-MS
MDA	Oxidative stress, lipid peroxidation	Plasma, Exhaled Breath	GC-MS	publication April 2018 Suitability of biomarkers of biological effects (BOBEs) for assessing the likelihood of reducing the tobacco related disease risk by new and innovative tobacco products: A literature review Scherer G Regulatory Toxicology and Pharmacology, Volume 94, doi: 10.1016/j.yrtph.2018.02.002 publication October 2017 Metabolomic Fingerprinting in Various Body Fluids of a Diet-Controlled Clinical Smoking Cessation Study Using a Validated GC-TOF-MS Metabolomics Platform Goettel M, Niessner R, Mueller D, Scherer M, Scherer G, Pluym N Journal of Proteome Research, Volume 16(10), doi: 10.1021/acs.jproteome.7b00128. Conference contribution October 2018 Identifying suitable biomarkers of biological effects (BOBEs) for evaluating reduced risk products Scherer G, Pluym N, Scherer M CORESTA Congress 2018, Biomarker Workshop, Kunming, China
Menthol	Flavor	Urine	HS-SPME-GC-MS
Methacrolein	Tobacco Smoke, E-Vapor Aerosol	ETS, e-liquids, aerosol	LC-MS/MS
Monohydroxybutenylmercapturic acid 1 (1-MHBMA)	1,3-Butadiene	Urine	LC-MS/MS	publication May 2015 Analysis of 18 urinary mercapturic acids by two high-throughput multiplex-LC-MS/MS methods Pluym N, Gilch G, Scherer G, Scherer M Analytical and Bioanalytical Chemistry, Volume 407, doi: 10.1007/s00216-015-8719-x Conference contribution October 2014 Analysis of 18 Urinary Mercapturic Acids by two Multiplex-LC-MS/MS Methods Pluym N, Gilch G, Scherer G, Scherer M CORESTA Congress 2014, Quebec, Canada publication October 2022 Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products Gerhard Scherer, Nikola Pluym, Max Scherer Drug Testing and Analysis DOI: 10.1002/dta.3372
Monohydroxybutenylmercapturic acid 2 (2-MHBMA)	1,3-Butadiene	Urine	LC-MS/MS	publication May 2015 Analysis of 18 urinary mercapturic acids by two high-throughput multiplex-LC-MS/MS methods Pluym N, Gilch G, Scherer G, Scherer M Analytical and Bioanalytical Chemistry, Volume 407, doi: 10.1007/s00216-015-8719-x Conference contribution October 2014 Analysis of 18 Urinary Mercapturic Acids by two Multiplex-LC-MS/MS Methods Pluym N, Gilch G, Scherer G, Scherer M CORESTA Congress 2014, Quebec, Canada publication October 2022 Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products Gerhard Scherer, Nikola Pluym, Max Scherer Drug Testing and Analysis DOI: 10.1002/dta.3372
N-Nitrosoanabasine (NAB)	NAB	Urine, ETS, Aerosol	LC-MS/MS, GC-MS	publication December 2009 Determination of tobacco-specific N-nitrosamines in urine of smokers and non-smokers Kavvadias D, Scherer G, Cheung F, Errington G, Shepperd J, McEwan M Biomarkers, Volume 14, doi: 10.3109/13547500903242883 publication March 2009 Simultaneous determination of four tobacco-specific N-nitrosamines (TSNA) in human urine Kavvadias D, Scherer G, Urban M, Cheung F, Errington G, Shepperd J, McEwan M Journal of Chromatography B, Volume 877, doi: 10.1016/j.jchromb.2009.03.009 publication March 2022 Assessment of the Exposure to Tobacco-Specific Nitrosamines and Minor Tobacco Alkaloids in Users of Various Tobacco/Nicotine Products Scherer G, Scherer M, Mütze J, Hauke T, Pluym N Chemical Research in Toxicology, doi: 10.1021/acs.chemrestox.2c00020
N-Nitrosoanatabine (NAT)	NAT	Urine, ETS, Aerosol	LC-MS/MS, GC-MS	publication December 2009 Determination of tobacco-specific N-nitrosamines in urine of smokers and non-smokers Kavvadias D, Scherer G, Cheung F, Errington G, Shepperd J, McEwan M Biomarkers, Volume 14, doi: 10.3109/13547500903242883 publication March 2009 Simultaneous determination of four tobacco-specific N-nitrosamines (TSNA) in human urine Kavvadias D, Scherer G, Urban M, Cheung F, Errington G, Shepperd J, McEwan M Journal of Chromatography B, Volume 877, doi: 10.1016/j.jchromb.2009.03.009 publication March 2022 Assessment of the Exposure to Tobacco-Specific Nitrosamines and Minor Tobacco Alkaloids in Users of Various Tobacco/Nicotine Products Scherer G, Scherer M, Mütze J, Hauke T, Pluym N Chemical Research in Toxicology, doi: 10.1021/acs.chemrestox.2c00020
N-Nitrosonornicotine (NNN)	NNN	Urine, Plasma, Saliva, ETS, Aerosol	LC-MS/MS, GC-MS	publication March 2014 Saliva as a matrix for human biomonitoring in occupational and environmental medicine Michalke B, Rossbach B, Göen T, Schäferhenrich A, Scherer G International Archives of Occupational and Environmental Health, volume 88, doi: 10.1007/s00420-014-0938-5 publication December 2009 Determination of tobacco-specific N-nitrosamines in urine of smokers and non-smokers Kavvadias D, Scherer G, Cheung F, Errington G, Shepperd J, McEwan M Biomarkers, Volume 14, doi: 10.3109/13547500903242883 publication March 2009 Simultaneous determination of four tobacco-specific N-nitrosamines (TSNA) in human urine Kavvadias D, Scherer G, Urban M, Cheung F, Errington G, Shepperd J, McEwan M Journal of Chromatography B, Volume 877, doi: 10.1016/j.jchromb.2009.03.009 Conference contribution October 2019 NNN a suitable biomarker of exposure from smoke and new nicotine delivery products? Pluym N, Taucher J, Scherer G, Scherer M CORESTA SSPT 2019, Hamburg, Germany Conference contribution October 2021 Quantitative analysis of NNN in plasma by LC-MS/MS: a suitable alternative to urinary determination to assess the exposure to this important toxicant Pluym N, Sibul F, Jin X, Edmiston J, Sarkar M, Scherer G, Scherer M CORESTA SSPT 2021, Virtual publication March 2022 Assessment of the Exposure to NNN in the Plasma of Smokeless Tobacco Users Pluym N, Scherer G, Edmiston J, Jin X, Sarkar M, Scherer M Chemical Research in Toxicology, doi:10.1021/acs.chemrestox.1c00431 publication March 2022 Assessment of the Exposure to Tobacco-Specific Nitrosamines and Minor Tobacco Alkaloids in Users of Various Tobacco/Nicotine Products Scherer G, Scherer M, Mütze J, Hauke T, Pluym N Chemical Research in Toxicology, doi: 10.1021/acs.chemrestox.2c00020
NNAL	NNK (Nicotine-derived nitrosamine ketone)	Urine	LC-MS/MS	publication January 2018 Review of biomarkers to assess the effects of switching from cigarettes to modified risk tobacco products Peck MJ, Sanders EB, Scherer G, Luedicke F, Weitkunat R Biomarkers, Volume 23(3), doi: 10.1080/1354750X.2017.1419284 publication December 2009 Determination of tobacco-specific N-nitrosamines in urine of smokers and non-smokers Kavvadias D, Scherer G, Cheung F, Errington G, Shepperd J, McEwan M Biomarkers, Volume 14, doi: 10.3109/13547500903242883 publication March 2009 Simultaneous determination of four tobacco-specific N-nitrosamines (TSNA) in human urine Kavvadias D, Scherer G, Urban M, Cheung F, Errington G, Shepperd J, McEwan M Journal of Chromatography B, Volume 877, doi: 10.1016/j.jchromb.2009.03.009 publication March 2022 Assessment of the Exposure to Tobacco-Specific Nitrosamines and Minor Tobacco Alkaloids in Users of Various Tobacco/Nicotine Products Scherer G, Scherer M, Mütze J, Hauke T, Pluym N Chemical Research in Toxicology, doi: 10.1021/acs.chemrestox.2c00020
NNK	Tobacco Smoke, Aerosol	ETS, Aerosol	LC-MS/MS
Nicotine (Nic)	Nicotine	Urine, Plasma, Serum, Saliva, PBS, ETS, e-liquids, aerosol	LC-MS/MS, GC-MS	publication March 2019 Biomarkers of Exposure Specific to E-vapor Products Based on Stable-Isotope Labeled Ingredients Landmesser A, Scherer M, Pluym N, Sarkar M, Edmiston J, Niessner R, Scherer G Nicotine & Tobacco Research, Volume 21, doi: 10.1093/ntr/nty204 publication May 2018 Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine Wang L, Bernert JT, Benowitz NL, Feng J, Jacob P 3rd, McGahee E, Caudill SP, Scherer G, Scherer M, Pluym N, Doig MV, Newland K, Murphy SE, Caron NJ, Sander LC, Shimizu M, Yamazaki H, Kim S, Langman LJ, Pritchett JS, Sniegoski LT, Li Y, Blount BC, Pirkle JL Cancer Epidemiology, Biomarkers & Prevention, Volume 27, doi: 10.1158/1055-9965 publication March 2014 Saliva as a matrix for human biomonitoring in occupational and environmental medicine Michalke B, Rossbach B, Göen T, Schäferhenrich A, Scherer G International Archives of Occupational and Environmental Health, volume 88, doi: 10.1007/s00420-014-0938-5 publication January 2014 Simple, fast and sensitive LC-MS/MS analysis for the simultaneous quantification of nicotine and 10 of its major metabolites Piller M, Gilch G, Scherer G, Scherer M Journal of Chromatography B, Volumes 951–952, doi: 10.1016/j.jchromb.2014.01.025 Conference contribution October 2013 Assessing the exposure to ‘smoke’ from electronic cigarettes by biomarkers Scherer G, Hagedorn H-W, Riedel K, Scherer M CORESTA SSPT 2013, Seville, Spain Conference contribution October 2016 Ultra-sensitive method for the determination of nicotine in PK studies with next generation products Wanderer F, Pluym N, Scherer G, Scherer M CORESTA Congress 2016, Berlin, Germany Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–study design Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution February 2018 Biomarkers of exposure specific to e-vapor products based on stable-isotope labeled ingredients Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N SRNT 2018, Baltimore, USA publication March 2022 Assessment of nicotine delivery and uptake in users of various tobacco / nicotine products Scherer G, Mütze J, Pluym N, Scherer M Current Research in Toxicology, Volume 3, 100067
Nicotine-N-oxide (NNO)	Nicotine	Urine	LC-MS/MS	publication March 2019 Biomarkers of Exposure Specific to E-vapor Products Based on Stable-Isotope Labeled Ingredients Landmesser A, Scherer M, Pluym N, Sarkar M, Edmiston J, Niessner R, Scherer G Nicotine & Tobacco Research, Volume 21, doi: 10.1093/ntr/nty204 publication May 2018 Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine Wang L, Bernert JT, Benowitz NL, Feng J, Jacob P 3rd, McGahee E, Caudill SP, Scherer G, Scherer M, Pluym N, Doig MV, Newland K, Murphy SE, Caron NJ, Sander LC, Shimizu M, Yamazaki H, Kim S, Langman LJ, Pritchett JS, Sniegoski LT, Li Y, Blount BC, Pirkle JL Cancer Epidemiology, Biomarkers & Prevention, Volume 27, doi: 10.1158/1055-9965 publication January 2014 Simple, fast and sensitive LC-MS/MS analysis for the simultaneous quantification of nicotine and 10 of its major metabolites Piller M, Gilch G, Scherer G, Scherer M Journal of Chromatography B, Volumes 951–952, doi: 10.1016/j.jchromb.2014.01.025 Conference contribution October 2013 Assessing the exposure to ‘smoke’ from electronic cigarettes by biomarkers Scherer G, Hagedorn H-W, Riedel K, Scherer M CORESTA SSPT 2013, Seville, Spain Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–study design Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution February 2018 Biomarkers of exposure specific to e-vapor products based on stable-isotope labeled ingredients Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N SRNT 2018, Baltimore, USA publication March 2022 Assessment of nicotine delivery and uptake in users of various tobacco / nicotine products Scherer G, Mütze J, Pluym N, Scherer M Current Research in Toxicology, Volume 3, 100067
Nicotine-glucuronide (Nic-gluc)	Nicotine	Urine	LC-MS/MS	publication March 2019 Biomarkers of Exposure Specific to E-vapor Products Based on Stable-Isotope Labeled Ingredients Landmesser A, Scherer M, Pluym N, Sarkar M, Edmiston J, Niessner R, Scherer G Nicotine & Tobacco Research, Volume 21, doi: 10.1093/ntr/nty204 publication May 2018 Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine Wang L, Bernert JT, Benowitz NL, Feng J, Jacob P 3rd, McGahee E, Caudill SP, Scherer G, Scherer M, Pluym N, Doig MV, Newland K, Murphy SE, Caron NJ, Sander LC, Shimizu M, Yamazaki H, Kim S, Langman LJ, Pritchett JS, Sniegoski LT, Li Y, Blount BC, Pirkle JL Cancer Epidemiology, Biomarkers & Prevention, Volume 27, doi: 10.1158/1055-9965 publication January 2014 Simple, fast and sensitive LC-MS/MS analysis for the simultaneous quantification of nicotine and 10 of its major metabolites Piller M, Gilch G, Scherer G, Scherer M Journal of Chromatography B, Volumes 951–952, doi: 10.1016/j.jchromb.2014.01.025 Conference contribution October 2013 Assessing the exposure to ‘smoke’ from electronic cigarettes by biomarkers Scherer G, Hagedorn H-W, Riedel K, Scherer M CORESTA SSPT 2013, Seville, Spain Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–study design Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution February 2018 Biomarkers of exposure specific to e-vapor products based on stable-isotope labeled ingredients Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N SRNT 2018, Baltimore, USA publication March 2022 Assessment of nicotine delivery and uptake in users of various tobacco / nicotine products Scherer G, Mütze J, Pluym N, Scherer M Current Research in Toxicology, Volume 3, 100067
Norcotinine	Nicotine	Urine	LC-MS/MS	publication March 2019 Biomarkers of Exposure Specific to E-vapor Products Based on Stable-Isotope Labeled Ingredients Landmesser A, Scherer M, Pluym N, Sarkar M, Edmiston J, Niessner R, Scherer G Nicotine & Tobacco Research, Volume 21, doi: 10.1093/ntr/nty204 publication May 2018 Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine Wang L, Bernert JT, Benowitz NL, Feng J, Jacob P 3rd, McGahee E, Caudill SP, Scherer G, Scherer M, Pluym N, Doig MV, Newland K, Murphy SE, Caron NJ, Sander LC, Shimizu M, Yamazaki H, Kim S, Langman LJ, Pritchett JS, Sniegoski LT, Li Y, Blount BC, Pirkle JL Cancer Epidemiology, Biomarkers & Prevention, Volume 27, doi: 10.1158/1055-9965 publication January 2014 Simple, fast and sensitive LC-MS/MS analysis for the simultaneous quantification of nicotine and 10 of its major metabolites Piller M, Gilch G, Scherer G, Scherer M Journal of Chromatography B, Volumes 951–952, doi: 10.1016/j.jchromb.2014.01.025 Conference contribution October 2013 Assessing the exposure to ‘smoke’ from electronic cigarettes by biomarkers Scherer G, Hagedorn H-W, Riedel K, Scherer M CORESTA SSPT 2013, Seville, Spain Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–study design Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution February 2018 Biomarkers of exposure specific to e-vapor products based on stable-isotope labeled ingredients Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N SRNT 2018, Baltimore, USA publication March 2022 Assessment of nicotine delivery and uptake in users of various tobacco / nicotine products Scherer G, Mütze J, Pluym N, Scherer M Current Research in Toxicology, Volume 3, 100067
Nornicotine	Nicotine	Urine	LC-MS/MS	publication March 2019 Biomarkers of Exposure Specific to E-vapor Products Based on Stable-Isotope Labeled Ingredients Landmesser A, Scherer M, Pluym N, Sarkar M, Edmiston J, Niessner R, Scherer G Nicotine & Tobacco Research, Volume 21, doi: 10.1093/ntr/nty204 publication May 2018 Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine Wang L, Bernert JT, Benowitz NL, Feng J, Jacob P 3rd, McGahee E, Caudill SP, Scherer G, Scherer M, Pluym N, Doig MV, Newland K, Murphy SE, Caron NJ, Sander LC, Shimizu M, Yamazaki H, Kim S, Langman LJ, Pritchett JS, Sniegoski LT, Li Y, Blount BC, Pirkle JL Cancer Epidemiology, Biomarkers & Prevention, Volume 27, doi: 10.1158/1055-9965 publication January 2014 Simple, fast and sensitive LC-MS/MS analysis for the simultaneous quantification of nicotine and 10 of its major metabolites Piller M, Gilch G, Scherer G, Scherer M Journal of Chromatography B, Volumes 951–952, doi: 10.1016/j.jchromb.2014.01.025 Conference contribution October 2013 Assessing the exposure to ‘smoke’ from electronic cigarettes by biomarkers Scherer G, Hagedorn H-W, Riedel K, Scherer M CORESTA SSPT 2013, Seville, Spain Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–study design Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution February 2018 Biomarkers of exposure specific to e-vapor products based on stable-isotope labeled ingredients Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N SRNT 2018, Baltimore, USA publication March 2022 Assessment of nicotine delivery and uptake in users of various tobacco / nicotine products Scherer G, Mütze J, Pluym N, Scherer M Current Research in Toxicology, Volume 3, 100067
PGF2α	Oxidative Stress	Urine	LC-MS/MS	publication April 2018 Suitability of biomarkers of biological effects (BOBEs) for assessing the likelihood of reducing the tobacco related disease risk by new and innovative tobacco products: A literature review Scherer G Regulatory Toxicology and Pharmacology, Volume 94, doi: 10.1016/j.yrtph.2018.02.002 publication March 2018 Analysis of Urinary Eicosanoids by LC-MS/MS Reveals Alterations in the Metabolic Profile after Smoking Cessation Goettel M, Niessner R, Scherer M, Scherer G, Pluym N Chemical Research in Toxicology, Volume 31, doi: 10.1021/acs.chemrestox publication October 2017 Metabolomic Fingerprinting in Various Body Fluids of a Diet-Controlled Clinical Smoking Cessation Study Using a Validated GC-TOF-MS Metabolomics Platform Goettel M, Niessner R, Mueller D, Scherer M, Scherer G, Pluym N Journal of Proteome Research, Volume 16(10), doi: 10.1021/acs.jproteome.7b00128. publication February 2012 A simple and robust UPLC-SRM/MS method to quantify urinary eicosanoids Sterz K, Scherer G, Ecker J Journal of Lipid Research, Volume 53, doi: 10.1194/jlr.D023739
Particulate matter (PM)	Tobacco Smoke	Environmental Tobacco Smoke (ETS)	Light scattering or gravimetry
Phenantrene (Phe)	PAH	ETS	GC-MS
Propionaldehyde (PA)	Tobacco Smoke, E-Vapor Aerosol	ETS, e-liquids, aerosol	LC-MS/MS
Propylene glycol (PG)	Propylene glycol	Urine, Plasma, Serum, Saliva, PBS, Aerosol, ETS, e-liquids	LC-MS/MS	publication March 2019 Biomarkers of Exposure Specific to E-vapor Products Based on Stable-Isotope Labeled Ingredients Landmesser A, Scherer M, Pluym N, Sarkar M, Edmiston J, Niessner R, Scherer G Nicotine & Tobacco Research, Volume 21, doi: 10.1093/ntr/nty204 Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria publication October 2021 1,2-Propylene Glycol: A Biomarker of Exposure Specific to e-Cigarette Consumption Burkhardt T, Pluym N, Scherer G, Scherer M Separations, 8, 180, doi: 10.3390/separations8100180 Conference contribution March 2022 Propylene glycol: A Biomarker of Exposure specific to E-Cigarette Consumption Burkhardt T, Pluym N, Scherer G, Scherer M SRNT 2022, Baltimore (Hybrid), USA Conference contribution September 2022 Propylene glycol as a specific biomarker for e-cigarette use Showcase of a novel Orbitrap-MS-based exposomics approach Nikola Pluym, Therese Burkhardt, Alpesh Kachhadia, Gerhard Scherer, Max Scherer ISES 2022, Lisbon
Prostaglandin D	Oxidative Stress	Urine	LC-MS/MS	publication April 2018 Suitability of biomarkers of biological effects (BOBEs) for assessing the likelihood of reducing the tobacco related disease risk by new and innovative tobacco products: A literature review Scherer G Regulatory Toxicology and Pharmacology, Volume 94, doi: 10.1016/j.yrtph.2018.02.002 publication March 2018 Analysis of Urinary Eicosanoids by LC-MS/MS Reveals Alterations in the Metabolic Profile after Smoking Cessation Goettel M, Niessner R, Scherer M, Scherer G, Pluym N Chemical Research in Toxicology, Volume 31, doi: 10.1021/acs.chemrestox publication October 2017 Metabolomic Fingerprinting in Various Body Fluids of a Diet-Controlled Clinical Smoking Cessation Study Using a Validated GC-TOF-MS Metabolomics Platform Goettel M, Niessner R, Mueller D, Scherer M, Scherer G, Pluym N Journal of Proteome Research, Volume 16(10), doi: 10.1021/acs.jproteome.7b00128. publication February 2012 A simple and robust UPLC-SRM/MS method to quantify urinary eicosanoids Sterz K, Scherer G, Ecker J Journal of Lipid Research, Volume 53, doi: 10.1194/jlr.D023739
Prostaglandin E	Oxidative Stress	Urine	LC-MS/MS	publication April 2018 Suitability of biomarkers of biological effects (BOBEs) for assessing the likelihood of reducing the tobacco related disease risk by new and innovative tobacco products: A literature review Scherer G Regulatory Toxicology and Pharmacology, Volume 94, doi: 10.1016/j.yrtph.2018.02.002 publication March 2018 Analysis of Urinary Eicosanoids by LC-MS/MS Reveals Alterations in the Metabolic Profile after Smoking Cessation Goettel M, Niessner R, Scherer M, Scherer G, Pluym N Chemical Research in Toxicology, Volume 31, doi: 10.1021/acs.chemrestox publication October 2017 Metabolomic Fingerprinting in Various Body Fluids of a Diet-Controlled Clinical Smoking Cessation Study Using a Validated GC-TOF-MS Metabolomics Platform Goettel M, Niessner R, Mueller D, Scherer M, Scherer G, Pluym N Journal of Proteome Research, Volume 16(10), doi: 10.1021/acs.jproteome.7b00128. publication February 2012 A simple and robust UPLC-SRM/MS method to quantify urinary eicosanoids Sterz K, Scherer G, Ecker J Journal of Lipid Research, Volume 53, doi: 10.1194/jlr.D023739
Pyrene (Pyr)	PAH	ETS	GC-MS
S-Benzylmercapturic acid (SBMA)	Toluene	Urine	LC-MS/MS	publication May 2015 Analysis of 18 urinary mercapturic acids by two high-throughput multiplex-LC-MS/MS methods Pluym N, Gilch G, Scherer G, Scherer M Analytical and Bioanalytical Chemistry, Volume 407, doi: 10.1007/s00216-015-8719-x Conference contribution October 2014 Analysis of 18 Urinary Mercapturic Acids by two Multiplex-LC-MS/MS Methods Pluym N, Gilch G, Scherer G, Scherer M CORESTA Congress 2014, Quebec, Canada publication October 2022 Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products Gerhard Scherer, Nikola Pluym, Max Scherer Drug Testing and Analysis DOI: 10.1002/dta.3372
S-Phenylmercapturic acid (SPMA)	Benzene	Urine	LC-MS/MS	publication October 2020 Benzene metabolite SPMA and acrylamide metabolites AAMA and GAMA in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V) Schwedler G, Murawski A, Schmied-Tobies MIH, Rucic E, Scherer M, Pluym N, Scherer G, Bethke R, Kolossa-Gehring M Environmental Research, Volume 192, doi: 10.1016/j.envres.2020.110295 publication May 2015 Analysis of 18 urinary mercapturic acids by two high-throughput multiplex-LC-MS/MS methods Pluym N, Gilch G, Scherer G, Scherer M Analytical and Bioanalytical Chemistry, Volume 407, doi: 10.1007/s00216-015-8719-x Conference contribution October 2014 Analysis of 18 Urinary Mercapturic Acids by two Multiplex-LC-MS/MS Methods Pluym N, Gilch G, Scherer G, Scherer M CORESTA Congress 2014, Quebec, Canada publication October 2022 Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products Gerhard Scherer, Nikola Pluym, Max Scherer Drug Testing and Analysis DOI: 10.1002/dta.3372
Solanesol	Tobacco Smoke	Environmental Tobacco Smoke (ETS)	LC-MS
Toluene	Tobacco Smoke	ETS	GC-MS
Trehalose	Trehalose	PBS	LC-MS/MS
UV-PM	Tobacco Smoke	Environmental Tobacco Smoke (ETS)	Photometry
Xylene	Tobacco Smoke	ETS	GC-MS
ortho-Toluidine	ortho-Toluidine	Urine, ETS	GC-MS	publication April 2006 Determination of three carcinogenic aromatic amines in urine of smokers and nonsmokers Riedel K, Scherer G, Engl J, Hagedorn H-W, Tricker AR Journal of Analytical Toxicology, Volume 30, doi: 10.1093/jat/30.3.187 publication November 2022 Assessment of the Exposure to Aromatic Amines in Users of Various Tobacco/Nicotine Products Gerhard Scherer, Kirsten Riedel, Nikola Pluym, Max Scherer ACS Omega, doi: 10.1021/acsomega.2c06130
para-Menthane-3,8-diol	Menthol	Plasma, Serum	LC-MS/MS
trans,trans-muconic acid (tt-MA)	Benzene	Urine	GC-MS
trans-3'-Hydroxycotinine (3-OH-Cot)	Nicotine	Urine, Plasma, Serum, Saliva	LC-MS/MS	publication March 2019 Biomarkers of Exposure Specific to E-vapor Products Based on Stable-Isotope Labeled Ingredients Landmesser A, Scherer M, Pluym N, Sarkar M, Edmiston J, Niessner R, Scherer G Nicotine & Tobacco Research, Volume 21, doi: 10.1093/ntr/nty204 publication May 2018 Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine Wang L, Bernert JT, Benowitz NL, Feng J, Jacob P 3rd, McGahee E, Caudill SP, Scherer G, Scherer M, Pluym N, Doig MV, Newland K, Murphy SE, Caron NJ, Sander LC, Shimizu M, Yamazaki H, Kim S, Langman LJ, Pritchett JS, Sniegoski LT, Li Y, Blount BC, Pirkle JL Cancer Epidemiology, Biomarkers & Prevention, Volume 27, doi: 10.1158/1055-9965 publication March 2014 Saliva as a matrix for human biomonitoring in occupational and environmental medicine Michalke B, Rossbach B, Göen T, Schäferhenrich A, Scherer G International Archives of Occupational and Environmental Health, volume 88, doi: 10.1007/s00420-014-0938-5 publication January 2014 Simple, fast and sensitive LC-MS/MS analysis for the simultaneous quantification of nicotine and 10 of its major metabolites Piller M, Gilch G, Scherer G, Scherer M Journal of Chromatography B, Volumes 951–952, doi: 10.1016/j.jchromb.2014.01.025 publication February 2014 Untargeted metabolomic profiling in saliva of smokers and nonsmokers by a validated GC-TOF-MS method Mueller DC, Piller M, Niessner R, Scherer M, Scherer G Journal of Proteome Research, Volume 13, doi: 10.1021/pr401099r Conference contribution October 2013 Assessing the exposure to ‘smoke’ from electronic cigarettes by biomarkers Scherer G, Hagedorn H-W, Riedel K, Scherer M CORESTA SSPT 2013, Seville, Spain Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–study design Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution February 2018 Biomarkers of exposure specific to e-vapor products based on stable-isotope labeled ingredients Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N SRNT 2018, Baltimore, USA publication March 2022 Assessment of nicotine delivery and uptake in users of various tobacco / nicotine products Scherer G, Mütze J, Pluym N, Scherer M Current Research in Toxicology, Volume 3, 100067
trans-3'-Hydroxycotinine-glucuronide (3-OH-Cot-gluc)	Nicotine	Urine	LC-MS/MS	publication March 2019 Biomarkers of Exposure Specific to E-vapor Products Based on Stable-Isotope Labeled Ingredients Landmesser A, Scherer M, Pluym N, Sarkar M, Edmiston J, Niessner R, Scherer G Nicotine & Tobacco Research, Volume 21, doi: 10.1093/ntr/nty204 publication May 2018 Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine Wang L, Bernert JT, Benowitz NL, Feng J, Jacob P 3rd, McGahee E, Caudill SP, Scherer G, Scherer M, Pluym N, Doig MV, Newland K, Murphy SE, Caron NJ, Sander LC, Shimizu M, Yamazaki H, Kim S, Langman LJ, Pritchett JS, Sniegoski LT, Li Y, Blount BC, Pirkle JL Cancer Epidemiology, Biomarkers & Prevention, Volume 27, doi: 10.1158/1055-9965 publication January 2014 Simple, fast and sensitive LC-MS/MS analysis for the simultaneous quantification of nicotine and 10 of its major metabolites Piller M, Gilch G, Scherer G, Scherer M Journal of Chromatography B, Volumes 951–952, doi: 10.1016/j.jchromb.2014.01.025 Conference contribution October 2013 Assessing the exposure to ‘smoke’ from electronic cigarettes by biomarkers Scherer G, Hagedorn H-W, Riedel K, Scherer M CORESTA SSPT 2013, Seville, Spain Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–study design Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients–results Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution October 2017 Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods Landmesser A, Pluym N, Scherer G, Sarkar M, Edmiston J, Scherer M CORESTA SSPT 2017, Kitzbühel, Austria Conference contribution February 2018 Biomarkers of exposure specific to e-vapor products based on stable-isotope labeled ingredients Landmesser A, Scherer M, Scherer G, Sarkar M, Edmiston J, Pluym N SRNT 2018, Baltimore, USA publication March 2022 Assessment of nicotine delivery and uptake in users of various tobacco / nicotine products Scherer G, Mütze J, Pluym N, Scherer M Current Research in Toxicology, Volume 3, 100067

Pioniere in der Biomarker-Forschung

Alle im ABF entwickelten Biomarker-Methoden wurden in Fachzeitschriften mit Peer-Review-Verfahren veröffentlicht. Eine Tatsache, die die Validität, Transparenz und wissenschaftliche Evidenz der Bioanalytik untermauert. Dies ist vor allem für Zulassungsanträge bei Regulatoren von Bedeutung.