Biomonitoring

We offer a broad range of LC-MS and GC-MS based methods for the quantitative determination of environmental chemicals and/or their specific metabolites in various biological matrices, such as urine, serum, plasma or saliva. Our methods are frequently used on biomonitoring campaigns to evaluate the (non-)occupational exposure to environmental chemicals.
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Biomarker
Exposure to
Matrix
Analytical Technique
Reference
1-Hydroxyphenanthrene (1-OH-Phe) Phenanthrene Urine LC-MS/MS
1-Hydroxypyrene (1-OH-Pyr) Pyrene Urine LC-MS/MS
1-Naphthol (1-Hydroxynaphthalene, 1-OH-Nap) Naphthalene Urine LC-MS/MS
2,2,4-Trimethyl-6(2H)-quinolinone (EQI) Ethoxyquin Urine LC-MS/MS
2-(4-amino-2-hydroxybenzoyl)benzoic acid (AHB) Uvinul A plus Urine LC-MS/MS
2-(4-diethylamino-2-hydroxybenzoyl)benzoic acid (DHB) Uvinul A plus Urine LC-MS/MS
2-(4-ethylamino-2-hydroxybenzoyl)benzoic acid (EHB) Uvinul A plus Urine LC-MS/MS
2-Hydroxy-1-phenylethylmercapturic acid (PHEMA 1) Styrene Urine LC-MS/MS
2-Hydroxy-2-phenylethylmercapturic acid (PHEMA 2) Styrene Urine LC-MS/MS
2-Hydroxyethylmercapturic acid (HEMA) Ethylene oxide, Alkylating agents Urine LC-MS/MS
2-Hydroxyfluorene (2-OH-Flu) Fluorene Urine LC-MS/MS
2-Hydroxyphenanthrene (2-OH-Phe) Phenanthrene Urine LC-MS/MS
2-Hydroxypropylmercapturic acid (2-HPMA) Propylene oxide Urine LC-MS/MS
2-Naphthol (2-Hydroxynaphthalene, 2-OH-Nap) Naphthalene Urine LC-MS/MS
3-Hydroxyphenanthrene (3-OH-Phe) Phenanthrene Urine LC-MS/MS
3-Hydroxypropylmercapturic acid (3-HPMA) Acrolein Urine LC-MS/MS
3-hydroxybenzo[a]pyrene (3-OH-BaP) Benzo[a]pyrene Urine LC-MS/MS
4-Hydroxyphenanthrene (4-OH-Phe) Phenanthrene Urine LC-MS/MS
7-Hydroxycitronellylic acid 7-Hydroxycitronellal Urine LC-MS/MS
8-Carboxygeraniol Geraniol Urine LC-MS/MS
9-Hydroxyphenanthrene (9-OH-Phe) Phenanthrene Urine LC-MS/MS
Acrylamidemercapturic acid (AAMA) Acrylamide Urine LC-MS/MS
Carboxyhemoglobin (COHb) Carbon monoxide (CO) Blood GC-MS
Cotinine Nicotine Urine, Plasma, Serum, Saliva LC-MS/MS
Creatinine Normalization of urinary biomarker concentrations Urine Photometry
Cyanoethylmercapturic acid (CEMA) Acrylonitrile Urine LC-MS/MS
Cyanoethylvalin (CeVal) Acrylonitrile Blood GC-MS/MS
Dihydroxybutenylmercapturic acid (DHBMA) 1,3-Butadiene Urine LC-MS/MS
Dihydroxypropylmercapturic acid (DHPMA) Glycidol Urine LC-MS/MS
Ethylmercapturic acid (EMA) Ethylating agents Urine LC-MS/MS
Glycidamidemercapturic acid (GAMA) Acrylamide Urine LC-MS/MS
Hildebrandt acid Geraniol Urine LC-MS/MS
Isoprenemercapturic acid (IPMA-3) Isoprene Urine LC-MS/MS
Lysmerol Lysmeral (Lilial, Butylphenyl methylpropional) Urine LC-MS/MS
MTCA (2-methyl-thiazolidine-4-carboxylic acid) Acetaldehyde Plasma, Urine LC-MS/MS
MTCG (2-methyl-thiazolidine-4-carbonyl-glycine) Acetaldehyde Plasma, Urine LC-MS/MS
Methylcarbamoylmercapturic acid (AMCC) N,N-Dimethylformamide Urine LC-MS/MS
Methylmercapturic acid (MMA) Methylating agents Urine LC-MS/MS
Monohydroxybutenylmercapturic acid 1 (1-MHBMA) 1,3-Butadiene Urine LC-MS/MS
Monohydroxybutenylmercapturic acid 2 (2-MHBMA) 1,3-Butadiene Urine LC-MS/MS
N-Nitrosonornicotine (NNN) NNN Urine, Plasma, Saliva, ETS, Aerosol LC-MS/MS, GC-MS
NNAL NNK (Nicotine-derived nitrosamine ketone) Urine LC-MS/MS
Propylene glycol (PG) Propylene glycol Urine, Plasma, Serum, Saliva, PBS, Aerosol, ETS, e-liquids LC-MS/MS
S-Benzylmercapturic acid (SBMA) Toluene Urine LC-MS/MS
S-Phenylmercapturic acid (SPMA) Benzene Urine LC-MS/MS
TBBA (tert-Butyl benzoic acid) Lysmeral (Lilial, Butylphenyl methylpropional) Urine LC-MS/MS
Thiazolidine-4-carbonyl-glycine (TCG) Formaldehyde Plasma, Urine LC-MS/MS
Thiazolidine-4-carboxylic acid (TCA) Formaldehyde Plasma, Urine LC-MS/MS
Thiocyanate (SCN) Hydrogen cyanide Plasma, Urine, Serum, Saliva GC-MS
ortho-Toluidine ortho-Toluidine Urine, ETS GC-MS
trans,trans-muconic acid (tt-MA) Benzene Urine GC-MS
trans-3'-Hydroxycotinine (3-OH-Cot) Nicotine Urine, Plasma, Serum, Saliva LC-MS/MS

Pioneers in biomarker research

Almost all of the biomarker methods developed at ABF were published in peer-reviewed journals, a fact that supports the validity, transparency and scientific evidence of the bioanalysis especially of importance for regulatory submissions