Bioanalytical Solutions for Pharma

Our comprehensive catalogue of bioanalytical services is tailored to meet the specific needs of your project, supporting pre-clinical and clinical trials. Backed by strict regulatory compliance, we offer integrated solutions to support our customers’ drug development journey from start to registration. With advanced analytical expertise and state-of-the-art equipment, we're your trusted partner in keeping pace with the latest trends in analytical chemistry.

ADME, DMPK & DDI Study Support

  • Comprehensive metabolite profiling
  • Quantitative bioanalysis for pharmacokinetic (PK), toxicokinetic (TK), pharmacodynamic (PD), drug-drug-interaction, and bioequivalence studies

Biomarker Identification & Analysis

  • Non-Targeted-Screening (NTS) with high-resolution LC-MS
  • Identification of metabolites and suitable biomarkers in plasma and other matrices
  • Method development and validation in compliance with ICH M10 Guidelines on Bioanalytical Method Validation and Sample Analysis
  • Transfer and cross-validation of proprietary methods

Physicochemical Characterization

  • Plasma stability studies
  • Identification of degradation product and drug impurities
  • Enantioselective separation of chiral substances

Targeted & Untargeted Metabolomics

  • Advanced non-targeted HR-MS workflows for metabolic profiling
  • Quantitative determination of fatty acid / amino acid metabolism, and inflammation and oxidative stress biomarkers
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metabolite

Bioanalytical Services for Small Molecules

Comprehensive Pharmacokinetic (PK), Toxicokinetic (TK) and Pharmacodynamic (PD) Studies

Metabolite Profiling, Identification and Structural Elucidation

Unlocking Insights with Biomarker Analysis

Do you have any questions about our services?

We would be happy to advise and support you with your project or your study. Send us your request and tell us your specific wishes.

Our biomarker methods

Biomarker
Exposure to
Matrix
Analytical Technique
Reference
11-dehydro-TXB2 Inflammation Urine LC-MS/MS
2,3-dinor-8-iso-PGF2α Oxidative Stress Urine LC-MS/MS
2,3-dinor-TXB2 Inflammation Urine LC-MS/MS
8-iso-PGF2α Oxidative Stress Urine LC-MS/MS
Leukotriene E4 Inflammation Urine LC-MS/MS
Metabolomics (GC) Urine, Plasma, Saliva, Exhaled Breath GC-TOF-MS
Metabolomics (LC) Urine, Plasma, Saliva LC-Orbitrap-MS
PGF2α Oxidative Stress Urine LC-MS/MS
Prostaglandin D Oxidative Stress Urine LC-MS/MS
Prostaglandin E Oxidative Stress Urine LC-MS/MS
sICAM-1 Inflammation Plasma ELISA

Pioneers in biomarker research

Almost all of the biomarker methods developed at ABF were published in peer-reviewed journals, a fact that supports the validity, transparency and scientific evidence of the bioanalysis especially of importance for regulatory submissions